Overall decay-corrected radiochemical yields of purified [F-18]fluoro fatty acids were higher (MW=49.0 +/- 4.5%, CH=23.6 +/- 3.5%, P<.05) with microwave heating and side-products were notably fewer.
Conclusion: For routine synthesis of [F-18]fluoro fatty acid analogs, microwave heating is faster, milder, cleaner, less variable and higher yielding than CH and therefore the preferred reaction method. (C) 2011 Elsevier Inc. All rights
“The aim of this paper is to provide a new tool to classify the nucleic acid sequences. The profiles based on the values characterizing DNA sequences find more (descriptors derived from recently introduced graphical representation) are used as a basis of classification schemes related to different aspects of
similarity of the sequences. New multicomponent similarity buy OTX015 measures based on these descriptors have been defined. Each component of the new measures can be analyzed separately. The new measures are consistent with the standard ones but they contain more detailed information. In particular, it has been shown that within the new approach one can define a quantity which converges to the standard similarity measure. An application of the multicomponent similarity measure to families of histone sequences demonstrates the power and efficiency of the method. (c) 2010 Elsevier Ltd. All rights reserved.”
“Introduction: 4-[C-11]Methylphenyl 2,4-diazabicyclo[3.2.2]nonane-2-carboxylate
([C-11]CHIBA-1001) is a newly developed positron emission tomography (PET) ligand for mapping alpha(7) nicotinic acetylcholine receptors. We investigated whole-body biodistribution and radiation dosimetry of [C-11]CHIBA-1001 in humans and compared the results with those obtained in mice.
Methods: Dynamic whole-body PET was carried out for three human subjects after administering a bolus injection of [C-11]CHIBA-1001. Emission scans were collected in two-dimensional mode over five bed positions. Regions of interest were placed over 12 organs. Radiation dosimetry was estimated from the residence times of these source organs using the OLINDA program. Biodistribution data from mice were also used for the prediction of radiation dosimetry in humans, and results with and those without accommodation of different SBI-0206965 ic50 proportions of organ-to-total-body mass were compared with the results from the human PET study.
Results: lit humans, the highest accumulation was observed in the liver, whereas in mice, the highest accumulation was observed in the urinary bladder. The estimated effective dose from the human PET study was 6.9 mu Sv/MBq, and that from mice was much underestimated.
Conclusion: Effective dose estimates for [C-11]CHIBA-1001 were compatible with those associated with other common nuclear medicine tests. Absorption doses among several organs were considerably different between the human and mouse studies.