\n\nMethod: Data for this study were derived from the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (N = 43,093), which included US adults aged 18 years and older. This study focused on the sub-sample of adults with DSM-IV-diagnosed bipolar I disorder (n = 1,548). The past-year prevalence

of 11 GMCs was examined. Associations between GMCs, bipolar I disorder, and disability measures (12-Itern Short-Form Health Survey) were tested using multivariate regression analyses.\n\nResults: Approximately 32.4% Pexidartinib of adults with bipolar I disorder had I or more GMCs. In the general population, diagnosis with bipolar I disorder was a significant risk factor for 7 of 11 GMCs in adjusted analyses. Among adults with see more bipolar I disorder, those with 1 or more GMCs evidenced significantly greater disability across all disability measures compared to those without a GMC. Individual GMCs were significantly

associated with physical, mental, and psychosocial disability in adjusted analyses and predicted specific patterns of disability.\n\nConclusions: GMCs were found disproportionately among persons with bipolar I disorder and associated with significant impairments in health and psychosocial functioning. Health care providers should screen for and treat GMCs in service populations including persons with bipolar disorder, given the heightened rates of morbidity, mortality, and disability that attend untreated GMCs in this client group. integrated and collaborative PXD101 treatment approaches could significantly improve overall functioning and quality

of life for persons with this treatable disorder. J Clin Psychiatry 2009;70(10):1407-1415 (C) Copyright 2009 Physicians Postgraduate Press, Inc.”
“Hf-Ni alloys are studied as a gate electrode for metal-oxide-semiconductor devices. The Hf-Ni solid-state amorphization couple encompasses several metallurgical phenomena which are investigated at the nanoscale and are correlated with the macroscopic electrical properties of devices. The dependence of the Fermi level position on the alloy composition is studied both on SiO2 and on HfO2. In order to isolate the effects of interfacial and dielectric charges and dipoles, the dependence of the vacuum work-function values on the composition is also studied. The Fermi level positions of the alloys do not depend linearly on the average composition of the alloys and are strongly affected by Hf enrichment at the HfNix/dielectric interface and the HfNix surface. We note a constant shift of 0.4 eV in the Fermi level position on HfO2 compared to SiO2. In addition, characterization of the composition, structure, and morphology reveals Kirkendall voids formation when the bottom layer consists of Ni, and an oxygen-scavenging effect when the bottom layer is Hf. (C) 2012 American Institute of Physics. [http://0-dx.doi.org.brum.beds.ac.uk/10.1063/1.