This systematic review used the GBD Study operations guidelines, which divide the world into 21 regions based on geography and epidemiological profiles.10 The purpose PI3K inhibitor of this study was to estimate the age-specific anti-HCV seroprevalence in each of
the 21 world regions in 1990 and in 2005 through a systematic review and meta-analysis of primary national data sources and articles published for peer review between 1980 and 2007. The seroprevalence was modeled using the age-averaging random effects generalized negative binomial spline model from DisMod III,11 the latest iteration of the generic disease modeling system for model-based meta-analysis for descriptive epidemiology, developed by the Institute of Health Metrics and Evaluation (IHME) at the University of Washington.
The results of this meta-analysis and the estimates produced by the models identify regions and age groups with high prevalence, and predict prevalence in areas where data are sparse or not available. The anti-HCV seroprevalence estimated in this systematic review is the first step towards https://www.selleckchem.com/products/Belinostat.html modeling the global burden of disease for HCV infection. EIA, enzyme immunoassay; GBD, Global Burden of Disease Study; HBV, hepatitis B virus; HCV, hepatitis C virus; HDV, hepatitis D virus; IHME, Institute of Health Metrics and Evaluation; MESH, Medical Subject Headings; NHANES, National Health and Nutrition Examination Survey;
PWID, persons who use injecting drugs; UI, uncertainty interval; WHO, World Health Organization. Three Ovid databases, Medline, Embase, and Cinahl, were used to allow for a thorough systematic literature search. An attempt was made to include gray literature and other databases, but was abandoned when the ability to search systematically varied widely. As part of a larger body of work to estimate global prevalence for hepatitis B, C, and D, these databases were simultaneously searched for articles published over a 27-year period (1980-2007) that reported the prevalence of hepatitis B, C, and D PD184352 (CI-1040) virus infections. Medical Subject Headings (MESH) were used to search articles and freetext to search article abstracts that contained (1) a term related to hepatitis B (HBV), C, or D (HDV) or their markers of infection, and (2) a term related to prevalence, incidence, or disease burden. Due to limited resources, the results were restricted to articles in English only, which exclude 14.8% of the articles found in this search prior to deduplication, and application of selection criteria (Fig. 1). Abstracts were screened and were required to report prevalence or incidence of hepatitis B or C. Articles were excluded if they reported prevalence from a high-risk population or if the data reported were incomplete.