The genetic polymorphism in the HRG gene was analysed by Western blot and single nucleotide polymorphism analysis. None PR-171 inhibitor of the women homozygous for the serine at residue 186 became pregnant whereas the women homozygous for proline at residue 186

had higher than expected pregnancy rates. As far as is known, this is the first study to show that a specific genetic polymorphism in the HRG gene of a woman affects her chances of becoming pregnant after IVF. The results may be essential in improving advice and IVF treatment for couples with unexplained infertility. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.”
“Purpose: To establish the first age-and gender-specific nomograms for single and two consecutive tests for post-void residual urine (PVR). Material and Methods: Healthy children aged 4-12 years were enrolled for two sets of uroflowmetry and PVR. The first PVR and the lower value of the two consecutive PVRs of each child with a voided volume >= 50 ml check details were included for construction of Single-and Dual-PVR nomograms. Children with possible urinary tract infection or lower urinary tract dysfunctions

were excluded. Results and Limitations: Totally, 1,128 children (583 boys and 545 girls) with a mean age of 7.7 +/- 2.2 years were eligible for analysis. The 95th percentile of Single-PVR for all children was 27.2 ml, or 19.2% of bladder capacity (BC), while Prexasertib supplier that for Dual-PVR were 11.2 ml or 6.0% of BC, respectively. Multivariate studies showed that PVR was positively associated with BC, negatively associated with age, higher in boys than girls, and higher in abnormal uroflow patterns. For children aged <= 6 years, a single PVR >30 ml or >21% BC, or repetitive PVR >20 ml or >10% BC can be regarded as elevated. For children aged >= 7 years, a single PVR >20 ml or 15% BC, or repetitive PVR >10 ml or 6%

BC can be redefined as elevated. Conclusions: Age, gender, and BC should be taken into considerations at interpretation of PVR tests in children. Repeating PVR test is recommended when a single PVR is higher than the 95th percentile of age-and gender-specific PVR. Neurourol. Urodynam. 32: 10141018, 2013. (C) 2013 Wiley Periodicals, Inc.”
“Ovulation induction (OI) or ovulation enhancement (OE) with gonadotrophins can be a reasonable treatment option for patients with a variety of infertility diagnoses. It must be used with extensive monitoring and management given the risk of multiple pregnancy, especially high-order multiples. This retrospective study evaluated per cycle outcomes of a large cohort of 1452 gonadotrophin OI/OE cycles at an academic infertility centre, and the efficacy of specific guidelines in limiting multiple pregnancy. The lowest possible gonadotrophin doses were used and cycle cancellation was recommended if more than three dominant follicles were present, and/or if serum oestradiol was above 1500 pg/ml.