The disorders Induced by alcohol are well known, and will not be detailed here. DSM-IV lists withdrawal delirium (delirium tremens), psychotic disorders

with delusions or hallucinations, persisting dementia, and persisting amnestic disorder. Recognizing the frequent association between alcohol and depression, DSM-W also Includes the category alcohol-induced mood disorder to diagnose mood disorders developing during, or within a month, of alcohol intoxication or withdrawal. Inhibitors,research,lifescience,medical Depression ami alcohol The Interrelationship between depression and alcohol Is complex, but highly Important in clinical practice. About 100 years ago, the readers of a booklet written by Bode, a German physician,7 could learn that depression and alcohoi abuse are often linked. The author thought that regular drinking could be a consequence of the “depression” caused by an unfavorable climate, stating for instance that alcoholism had been observed in Italians moving to the fog and rain Inhibitors,research,lifescience,medical of London, or in German colonial officers posted In tropical countries. In a more modern vein, Inhibitors,research,lifescience,medical Bode also added

that alcohol abuse could be one of the first symptoms of “melancholia,” the usual term at the time for today’s major depression. He wrote that the melancholic patient “turned to the bottle” to alleviate feelings of anxiety, guilt, sorrow, sadness, and mental vacuity. This statement would still be considered Inhibitors,research,lifescience,medical pertinent today Intuitively, the association between depression and alcohol seems to have good face value. However, this association Is much more complex than meets the eye. Interestingly, a Ushaped relationship of depression and alcohol consumption has been observed In large population samples. It was found that lower-level drinkers had lower depression scores than both nondrinkers and heavy drinkers.8 The fact that moderate alcohol users are merrier than teetotalers Is Illustrated

by Sir John’s comment in Shakespeare’s play, Henry IV, Part 2 (act Inhibitors,research,lifescience,medical 4): “A man cannot make him laugh; but that’s no marvel; he drinks no wine.” The causal element In the association between depression Batimastat and alcoholism is debatable. Is depression secondary to alcoholism, or vice versa? Or, are both possible? In the case of alcohol-Induced mood disturbances, alcoholism Is clearly primary, and depression secondary. Mood disturbances are characteristic of heavy drinkers, particularly during withdrawal. When not drinking, alcoholics often report depression, Irritability, suspiciousness, lethargy, apprehension, anxiety, and poor concentration. About a quarter of recently detoxified alcoholics have a depressive NSC-737664 syndrome. Alcohol-induced depression usually remits In less than 1 month without specific treatment. The clinical course of depression when it coexists with alcoholism Is generally benign and self-limited, with most patients becoming euthymlc within 2 to 3 weeks of abstention without antidepressant treatment.