The basal and BCR induced phosphorylation of LYN and JNK were examined by immunoblottting. Cell survival signs were examined by apoptosis using flow cytometry. We confirmed that LYN was constitutively phosphorylated in MCL cell lines and in 9/10 leukemic MCL cases. Therapy with dasatinib or with a particular inhibitor of Cilengitide clinical trial Src kinases such as PP2 suppressed constitutive LYN service and improved in vitro spontaneous apoptosis of primary MCL cells. BCR proposal led to a rise of LYN phosphorylation resulting in activation of c JUN NH2 terminal kinase and over expression of the early growth response gene 1. Inhibition of JNK with SP600125 induced apoptosis and reduced amount of basal and BCR induced expression of EGR 1. Moreover, decreasing EGR1 expression by siRNA paid down BCRinduced cell survival. Treatment with PP2 or with JNK Cellular differentiation phosphorylation as and dasatinib suppressed BCR induced LYN well as EGR 1 upregulation and is associated with a cases analysed cell survival in decrease of. . This research illustrates the significance of BCR signaling in MCL cell survival and points out for the effectiveness of kinase inhibitors in suppressing proximal BCR signaling functions and in inducing apoptosis. Keywords: Mantle cell lymphoma, LYN, BCR, EGR 1, Dasatinib Back ground Mantle cell lymphoma constitutes about 10% of non Hodgkin lymphoma and despite recent advances in the treatment, the condition hasn’t usually been cured with a bad progression free survival for a large number of patients. New treatments that target specific signaling molecules are for that reason of possible value. Recently, some studies tried to reveal new acceptable therapeutic objectives and have Cabozantinib Tie2 kinase inhibitor clarified the influence of many signaling pathways for increased proliferation and resistance to apoptosis of MCL cells. Constitutively lively B cell receptor mediated signaling is implicated in the pathogenesis of numerous NHLs including diffuse large B cell lymphoma, follicular lymphoma, gastric mucosa-associated lymphoid tissue lymphoma and B cell chronic lymphocytic leukaemia. Recently, we demonstrated in major MCL cells a central position for effective BCR signs in success of MCL cells. The activated forms of spleen tyrosine kinase and the BCR related kinases LYN were present in MCL tumor tissues therefore supporting an in vivo function of active BCR signaling in this pathology. Furthermore, MCL is indicated by a highly limited immunoglobulin gene arsenal with stereotyped VH CDR3s and correct Somatic Hyper Mutation targeting, hence clearly implying a job for antigen driven collection of the clonogenic progenitors. Upon antigen proposal, Ig IgB heterodimer are phosphorylated on immunoreceptor tyrosine centered activation motif tyrosines by the BCR related kinase LYN, which belongs to the Src family kinases. Early BCR induced genes were discovered by qRT PCR array.