PubMed 27. Schaber JA, Carty NL, McDonald NA, Graham ED, Cheluvappa R, Griswold JA, Hamood AN: Analysis of quorum sensing-deficient clinical isolates of Pseudomonas aeruginosa. J Med Microbiol 2004, 53:841–853.PubMedCrossRef 28. Davey ME, YM155 clinical trial Caiazza NC, O’Toole GA: Rhamnolipid surfactant production affects biofilm

architecture in Pseudomonas aeruginosa PAO1. J Bacteriol 2003, 185:1027–1036.PubMedCrossRef 29. Sakuragi Y, Kolter R: Quorum-sensing regulation of the biofilm matrix genes (pel) of Pseudomonas aeruginosa. J Bacteriol 2007, 189:5383–5386.PubMedCrossRef 30. Shrout JD, Chopp DL, Just CL, Hentzer M, Givskov M, Parsek MR: The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional. Mol Microbiol 2006, 62:1264–1277.PubMedCrossRef 31. Kessler E, Safrin M, Olson JC, Ohman DE: Secreted LasA of Pseudomonas aeruginosa is a staphylolytic protease. J Biol Chem 1993, 268:7503–7508.PubMed 32. Machan ZA, Taylor GW, Pitt TL, Cole PJ, Wilson R: 2-Heptyl-4-hydroxyquinoline

N-oxide, an antistaphylococcal agent produced by Pseudomonas aeruginosa. J Antimicrob Chemother 1992, 30:615–623.PubMedCrossRef 33. Davies DG, Marques CN: A fatty acid messenger is responsible for inducing dispersion in microbial biofilms. J Bacteriol 2009, 191:1393–1403.PubMedCrossRef 34. Lagendijk EL, Validov S, Lamers GE, de Weert S, Bloemberg GV: Genetic tools for tagging Gram-negative bacteria with mCherry for visualization in vitro and in natural habitats, biofilm and EVP4593 nmr pathogenicity studies. FEMS Microbiol Lett 2010, 305:81–90.PubMedCrossRef 35. Schaber JA, Hammond A, Carty NL, Williams SC, Colmer-Hamood JA, Burrowes BH, Dhevan V, Griswold JA, Hamood AN: Diversity of biofilms produced by quorum-sensing-deficient clinical isolates of Pseudomonas aeruginosa. J Med Microbiol 2007, 56:738–748.PubMedCrossRef 36. Henke MO, John G, Germann M, Lindemann H, Rubin BK: MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbation.

Am J Respir Crit Care Med 2007, 175:816–821.PubMedCrossRef 37. Li JD, Dohrman AF, Gallup M, Miyata S, Gum JR, Kim YS, Nadel JA, Prince A, Basbaum CB: Transcriptional activation of mucin by Pseudomonas Florfenicol aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc Natl Acad Sci U S A 1997, 94:967–972.PubMedCrossRef 38. Li JD, Feng W, Gallup M, Kim JH, Gum J, Kim Y, Basbaum C: Activation of NF-kappaB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells. Proc Natl Acad Sci U S A 1998, 95:5718–5723.PubMedCrossRef 39. Yan F, Li W, Jono H, Li Q, Zhang S, Li JD, Shen H: Reactive oxygen species regulate Pseudomonas aeruginosa lipopolysaccharide-induced MUC5AC mucin expression via PKC-NADPH oxidase-ROS-TGF-alpha signaling pathways in human airway epithelial cells. Biochem Biophys Res Commun 2008, 366:513–519.PubMedCrossRef 40.