On behalf of his employer, D. S. http://www.selleckchem.com/products/17-AAG(Geldanamycin).html Baldwin has received honoraria for educational presentations from Lundbeck, and has acted as a paid consultant to Eli Lilly, GlaxoSmithKline, Grunenthal, Lundbeck, Pfizer Inc, Pierre Fabre and Servier, and currently holds research grants (on behalf of his employer) from Lundbeck and Pfizer Inc. He has accepted paid speaking
engagements in industry-supported satellite symposia or other meetings hosted by Eli Lilly, GlaxoSmithKline, Lundbeck, Pfizer Inc, Pierre Fabre and Servier. R. Pedersen is a Pfizer Inc employee and stockholder. A. Szumski is an employee of Inventiv Health Inc who is a paid contractor Inhibitors,research,lifescience,medical to Pfizer Inc. B. O. Rothbaum has no conflicts of interests to declare.
Fatigue is described as an most overwhelming, abnormal feeling of extreme Inhibitors,research,lifescience,medical tiredness or exhaustion, which cannot be cured by rest or sleep. A majority of individuals with multiple sclerosis (MS) report fatigue as their most common symptom and also as their single most disabling symptom (Bakshi 2003; Krupp et al. 2010). In one study, 68% reported fatigue as either their worst or as one of their worst symptoms (Flensner et al. 2008). In a study of almost 1500 MS patients registered in the National Swedish MS-register, almost
25% of the patients without any disability and almost 50% of those with mild disability reported fatigue Inhibitors,research,lifescience,medical (Landtblom et al. 2004). Thus, fatigue is very common in MS and it also may start early in the disease course (Freal et al. 1984). Unfortunately, there is sometimes lacking interest Inhibitors,research,lifescience,medical and the knowledge
about this key symptom in MS within health care is varying. Fatigue should be monitored at the clinical visits, and there are useful instruments like the Fatigue Severity Inhibitors,research,lifescience,medical Scale (FSS) (Krupp et al. 1988) and Fatigue Impact Scale (FIS) (Fisk et al. 1994a) for such purposes. MS-related fatigue is defined as both primary and secondary fatigue. Primary fatigue is believed as caused by the disease itself, including centrally mediated processes like demyelination, axonal loss in the central nervous system (CNS), or immunological factors, as well as potential peripheral symptoms at the muscular level. Secondary AV-951 fatigue is due to other influencing factors, for example, sleep problems, depression, pain, and side effects of medication (Kos et al. 2008). Central fatigue can be described as a failure to initiate and maintain both physical and mental tasks that require self-motivation in the absence of (or not related to) cognitive and motor dysfunction (Chaudhuri and Behan 2000, 2004). Despite the fact that fatigue is a common and debilitating symptom in MS, it remains a challenge. This is because no definite pathogenesis behind the symptom fatigue has been identified, although it is obvious that many factors seem to be involved.