For example, in one study of factors related to penile bulb dose, postimplant MRI/CT fusion showed that a decrease in the distance

from the prostate apex to the penile bulb (which ranged from 5 to 33 mm in that study) correlated with increased penile bulb dose, with approximately one-third of patients receiving potentially clinically significant penile bulb doses (23). Increased dose to the Buparlisib penile bulb has been associated with the development of postbrachytherapy erectile dysfunction in several reports [24] and [25], although this association is not conclusive [26] and [27]. Regardless, the use of MRI for treatment planning would allow improved treatment accuracy and improved AZD4547 in vitro ability to quantify dosimetric factors associated with treatment-related morbidity. Another possible benefit of better anatomic visualization is improved control over dose heterogeneity. Accurate visualization of prostate glandular tissue and the urethra would allow improved urethral sparing and facilitate dose escalation to dominant lesions. In fact, advanced MRI techniques

such as MRI spectroscopy have been explored for dose escalation using brachytherapy [28] and [29] and external beam radiation therapy (30). Successful implementation of MRI for pretreatment planning will require the ability to use MRI guidance Urocanase in the operating room. The feasibility of intraoperative MRI for prostate brachytherapy has been demonstrated by the Brigham and Women’s/Dana Farber Cancer Center group (18). In that series, an open MRI was used to perform the implants with real-time intraoperative imaging, using intraoperative planning and optimization. Another study from the same group showed that prostate deformation is seen with pretreatment erMRI when compared with intraoperative MRI (31). These findings are consistent with the gland deformation seen in the present study and underscore the importance of accurate integration of

pretreatment and intraoperative MRI, which is of particular importance when using preplanning techniques. Another means of using MRI in preplanning is MRI/TRUS fusion. Fusing MRI to TRUS has been shown to be feasible and to improve visualization of the prostate, particularly with respect to identifying the base and apex slices on TRUS [32] and [33]. Those studies demonstrated that TRUS underestimated the extent of the prostate at both the base and the apex. Conversely, we found that TRUS overestimated prostate length, highlighting the interoperator variability inherent with TRUS; presumably this variability could be improved by using MRI/TRUS fusion. A previous dosimetric study compared TRUS-based and MRI-based preplanning and used MRI/TRUS fusion to confirm the reliability of MRI for preplanning (34).