It could also be derived from the accelerated stability study
that the optimised proportion of ACEL showed stabilisation of metastable amorphous form of the drug and non-progressive reappearance of a few diffraction peaks in XRPD study had a minimal effect on solubility characteristics of ACEL. Thus the present study provides a broader perspective of utilisation of innovative manufacturing technologies such as hot melt extrusion to enhance solubility characteristics of APIs showing thermal degradation; when processed only in combination Vorinostat chemical structure with suitable polymer–plasticiser system. All authors have none to declare. “
“Malaria ranks among the major health problems in Pakistan. Endemic in ninety-one countries which consist of forty percent of the world population, malaria affects an estimated 300 million people per year worldwide causing
more than a million deaths per year.1 Majority of the fatalities occur in children under five years of age. Pregnant women and non-immune people are at particular risk. Climate change is also expected to affect malaria indirectly by changing ecological relationships that are important to the organisms involved in malaria transmission (the vector, parasite and host). Examples of such indirect forces Selleckchem BMS777607 are deforestation and habitat changes due to climate change that may affect which species of Anopheles are able to survive. The three main climate factors that affect malaria are temperature, precipitation, and relative humidity. 2 Climate predicts, to a large degree, the natural distribution of malaria. 3 Epidemics of malaria are caused by a disturbance in equilibrium between host, parasite and vector. Najera et al 4 have defined
three different types of epidemics. Type I epidemics are caused by meteorological conditions, which create temporary epidemics that eventually revert back to the previous condition. Type II epidemics are caused by landscape Levetiracetam changes or colonization of sparsely populated areas that create a new equilibrium level of endemicity. Type III epidemics are caused by interruptions in measures that were controlling malaria. Plasmodium vivax and Plasmodium falciparum cause different types of epidemics. P. vivax epidemics occur mainly in areas with only seasonal transmission and show a bimodal peak, the second peak caused by relapses, whereas P. falciparum epidemics grow slowly and then explode causing only one peak of transmission. 4 The aim of present study is to determine the prevalence of plasmodium falciparum and plasmodium vivax in a population of Bannu district (N.W.F.P), and also to evaluate the effect and extent on patient blood chemistry, such as bilirubin, Glucose, ALT and AST and creatinine, due to these parasites in severe case of malaria.