(B) Uncorrected group differences in lobar cortical grey matter volumes after controlling for age, gender, and handedness (*Significant group difference at P < 0.006). ... Cortical thickness Vertex-wise and lobe-wise analyses on uncorrected data as well as data corrected for multiple comparisons at 5% False Discovery

Rate showed no significant group differences in CT within left or right hemispheres. Figure 1A presenting the overall mean CT values by group illustrates this Inhibitors,research,lifescience,medical effect. Surface area Results uncorrected for total SA indicated that relative to controls, the ARND group had significant reductions in left and right MLN8237 ic50 frontal (P = 0.005 and 0.002), left and right temporal (P = 0.006 and 0.001), and right occipital (P = 0.004) lobes (see Fig. 1C). The ARND group also showed a reduction in total SA (F = 8.31, P = 0.005 Cohen’s d = 0.73). However, when we controlled for this global effect, only the right

temporal lobe SA approached significant, (F = 3.86, P = 0.05, Cohen’s Inhibitors,research,lifescience,medical d = 0.78). Further vertex-wise analyses revealed these SA abnormalities were confined to the right superior temporal gyrus and a region between the right temporal and occipital cortices, t(86) = −2.81, q < 0.05 (see Fig. 1D). Age trajectories No significant age by group interactions were found on measures of CT and SA at both the hemispheric and lobar levels. The main Inhibitors,research,lifescience,medical effects of age on Inhibitors,research,lifescience,medical total brain volume (F = 2.27, P = 0.09), total SA (F = 2.56, P = 0.32), and mean CT (F = 1.45, P = 0.59) were not significant. Discussion This study aimed to determine whether children with ARND differed from typically developing controls in cortical morphometry measures. We observed global brain volume reductions in frontal, parietal, temporal cortical regions in the ARND group; however,

these reductions did not reflect Inhibitors,research,lifescience,medical CT abnormalities as groups did not differ on this index. Instead, the ARND group showed significant cortical SA reductions in bilateral frontal and temporal and right occipital regions and after old we controlled for global effects, local reductions in SA of the right temporal lobe approached significance. Vertex-wise analyses also revealed these SA reductions were confined to the right superior temporal gyrus and the right occipital-temporal area. Our findings concur with past research showing that fetal-alcohol-affected individuals have global grey matter volume reductions in frontal, temporal, and parietal lobes. In addition, as observed in previous studies (Mattson et al. 1994; Archibald et al. 2001; Bjorkquist et al. 2010), the effects did not remain significant when we corrected for total brain volume. The current findings also parallel past research that showed reduced surface extent in FASD, particularly in the orbitofrontal regions (Sowell et al. 2002).